The Role of Neuroendocrine Activity in The Regulation of The Immune Reactivity of The Organism in An Experimentally Created Extreme Situation

Authors

  • M.G. Mammadov National Oncology Center, Baku, Azerbaijan
  • T.A. Salimli Azerbaijan Medical University, Scientific Research Center, Department of Experimental Endocrinology, Baku, Azerbaijan
  • Y.B. Ismayilov Azerbaijan Medical University, Scientific Research Center, Department of Experimental Endocrinology, Baku, Azerbaijan
  • A.T. Ismayilova Azerbaijan Medical University, Scientific Research Center, Department of Experimental Endocrinology, Baku, Azerbaijan

DOI:

https://doi.org/10.61788/njn.v1i23.06

Keywords:

extreme condition, heavy metal, monoamine, immune status, hormone, toxic stress

Abstract

The activity of the body's immune reactivity changes because it disrupts the neuroendocrine interaction mechanism in the experimental extreme state created by cobalt acetate and in the subsequent period. Therefore, due to this effect, the mechanism of normal regulation between the neuroimmunoendocrine systems of the body is disturbed and deep pathologies of various nature occur. Research in the direction of such mutual regulation mechanism is important. It is also recommended to conduct an examination of the immune reactivity of people living in areas contaminated with heavy metals.

References

Булгакова С.В., Романчук Н.П. Иммунный гомеостаз: новая роль микро- и макроэлементов, здоровой микробиоты // Бюллетень науки и практики, 2020, Т. 6,№10, с. 206-233.

Дмухальская Е.Б. Состояние иммунной системы у крыс разного возраста,при действия тяжелых металлов и раундапа // Universum: Xимия и биология, электрон. научн. журн. 2018, №9 (51), с.3-6.

Котельникова С.В. Нейроэндокринный гомеостаз в условиях токсического стресса при различных режимах освещенности. Дис. докт. биол. наук, Астархань, 2015, 300 с.

Корнева Е.А. Пути взаимодействия нервной и иммунной систем: История и современность, клиническое применение // Медицинская иммунология, 2020, Т. 22, № 3, с. 405-418.

Лужецкий К.П. Гигиенические основы системы профилактики у детей эндок ринных заболеваний, ассоциированных с воздействием химических факторов окружающей среды селитебных територий. Дис. док. мед.наук. Пермь, 2017, 371 с.

Марченкова Е.А., Оттева Е.Е. Токсическое воздействие тяжелых металлов на живые организмы // Молодежь, наука, творчество - 2019. Матер. XVII межвузовской научно-практической конфер. студентов и аспирантов. 2019, с. 439-443.

Cao J., Xu X, Zhang Y., et al. Increased memory Tcell populations in Pb-exposed children from an e-waste-recycling area // Sci Total Environ. 2018 Mar,p.616-617.

Doeselaar L., Yang H., Bordes J., Brix L., et al. Chronic social defeat stress infema le mice leads to sex-specific behavioral and neuroendocrine effects // Stress. 2021, № 24(2),p.168-180.

Johnson J.D., Barnard D.F., Kulp A.C. Neuroendocrine regulation of brain cyto kines after psychological stress // J. Endocr. Soc., 2019,v. 14,№ 3(7), p. 1302-1320.

Jalsrai A., Biswas A., Suslov N.I., Martin J.V. Neuropsychopharmacological profi le of Astragalus membranaceous var. Mongholicus // Journal of Traditional Chinese Medical Sciences. 2019,№6(3),p.254-262.

Ebrahimi M., Khalili N., Razi S., et al. Effects of lead and cadmium on the immu ne system and cancer progression // J Environ Health Sci Eng. 2020, Feb 17,№18(1), p. 335-343.

Huo J., Dong A., Niu X., et al. Effects of cadmium on oxidative stress activities in plasma of freshwater turtle Chinemys reevesii. Environ Sci Pollut Res. 2018,№25(8), p. 8027-34.

Ismailov Y.B., Ismailova A.T., Jafarova Q.K., Salimli T.A., Garayeva S.Q. The effect of heavy metal on the hormonal-mediator status / Karadeniz 1. Uluslararası multidisipliner çalışmalar konqresi, Giresun ,2019.s.39-44.

Rafique S, Gillani SS, Nazir R . Lead and Cadmium Toxic Effects on Human Heal th: A Review // J Nutr Food Sci. 2021, №11,p.1-6.

Zhang Y., Xu X., Sun D., et al. Alteration of the number and percentage of innate immune cells in preschool children from an e-waste recycling area // Ecotoxicol Environ Saf. 2017 Nov; 145,p.615-622.

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Published

30.06.2023

How to Cite

Mammadov, M., Salimli, T., Ismayilov, Y., & Ismayilova, A. (2023). The Role of Neuroendocrine Activity in The Regulation of The Immune Reactivity of The Organism in An Experimentally Created Extreme Situation. National Journal of Neurology, 45–51. https://doi.org/10.61788/njn.v1i23.06

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Original Articles