Myeloproliferative Diseases as A Cause of Acute Cerebrovascular Accident

Abstract

Among the hemorheological forms of thrombophilia, chronic myeloproliferative diseases (CMPD) play an important role: polycythemia vera, essential thrombocythemia, primary myelofibrosis, the complications of which are arterial and venous thrombosis, including acute cerebrovascular accident (ACV). Identification of changes in the hemogram in such patients requires a thorough examination to exclude CMPD: monitoring of hemogram parameters in dynamics, hemostasiological examination, and determination of the level of erythropoietin, spleen size, and molecular-genetic study. Patients with chronic MPD and stroke need to start cytoreductive therapy (α-interferons, hydroxyurea) in a timely manner, conduct active long-term antithrombotic treatment (anticoagulants, antiplatelet agents) in order to prevent thromboembolism and improve the prognosis of the disease.