Neurological and Psychological Manifestations of COVID-19
DOI:
https://doi.org/10.61788/njn.v2i20.02Keywords:
COVID-19, SARS-CoV-2, pandemicAbstract
The present literature review discusses neuropsychological manifestations of COVID-19. Articles published in the recent months present neurological and psychological syndromes in patients with SARS-CoV-2 virus. The presented review is devoted to the analysis of the spectrum of neuropsychological syndromes and their pathophysiological mechanisms of development in patients with COVID-19.
References
Соловьева Н.В., Макарова Е.В., Кичук И.В. “Коронавирусный синдром”: профилактика психотравмы, вызванной COVID-19 // РМЖ, 2020 - N9.- C. 18-22.
Ahmed MU, Hanif M, Ali MJ, Haider MA, Kherani D, Memon GM, Karim AH and Sattar A (2020) Neurological Manifestations of COVID-19 (SARS-CoV-2): A Review // Front. Neurol. 11:518. doi: 10.3389/fneur.2020.00518.
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms // ACS Chem Neurosci. (2020) 11:995-8. doi: 10.1021/acschemneuro.0c00122.
Bangalore S, Sharma A, Slotwiner A, Yatskar L, Harari R, Shah B, et al. ST-Segment Elevation in Patients with Covid-19 - A Case Series // N Engl J Med. 2020 Apr;NEJMc2009020.
Brann D TT, Weinreb C, Logan D, Datta S. Non-neural exporessio of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms of underlying anosmai in COVID-19 // Biorxiv.org; 2020.
Brooks M. COVID-19 Tied to Wide Range of Neuropsychiatric Complications - Medscape - Jun 29, 2020. https://www.medscape.com/viewarticle/933136
Chen N., Zhou M., Dong X. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study // Lancet. 2020;395:507-513.
Clerkin KJ, Fried JA, Raikhelkar J, et al Coronavirus disease 2019 (Covid-19) and cardiovascular disease // Circulation 2020 Mar 21. doi:10.1161/CIRCULATIONAHA.120.046941
Dinakaran D, Manjunatha N., Naveen Kumar C., and Suresh B.M.Neuropsychiatric aspects of COVID-19 pandemic: A selective review // Asian J Psychiatr. 2020 Oct; 53: 102188.
Gutiérrez-Ortiz C, Méndez A, Rodrigo-Rey S, Pedro-Murillo ES, Bermejo-Guerrero L, Gordo-Mañas R, et al. Miller Fisher Syndrome and polyneuritis cranialis in COVID-19 // Neurology. (2020). doi: 10.1212/WNL.0000000000009619
Gustavo C. Román, Peter S. Spencer, Jacques Reis, Alain Buguet, et all. The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries // J Neurol Sci. 2020 Jul 15; 414: 116884.
Hess D.C., Eldahshan W., Rutowski E. COVID-19 -Related Stroke // Transl Stroke Res. 2020 Jun;11(3):322-325.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China // Lancet. 2020 Feb;395(10223):497-506.
Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor // Cell 2020;181:271-80.e8 doi:10.1016/j.cell.2020.02.052 pmid:32142651.
Jin Q. Tong. Rhabdomyolysis as potential complication associated with 2019 novel coronavirus disease // Emerg. Infect. Dis. 2020;26 doi: 10.3201/eid2607.200445. Published online March 3, 2020.
Lechien J.R., Chiesa-Estomba C.M., De Siati D.R. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study. Eur. Arch. Otorhinolaryngol. 2020 doi: 10.1007/s00405-020- 05965-1. Published online April 2, 2020.
Li Y.C., Bai W.Z., Hashikawa T. The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients // J. Med. Virol. 2020 doi: 10.1002/jmv.25728. Published online Feb 27, 2020.
Lee Y., Min P., Lee S., et al. Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients // J Korean Med Sci. 2020 May 11; 35(18): e174. doi: 10.3346/jkms.2020.35.e174.
Mao L., Jin H., Wang M. Neurologic manifestations of hospitalized patients with Coronavirus Disease 2019 in Wuhan, China // JAMA Neurol. 2020 doi: 10.1001/jamaneurol.2020.1127. Published online April 10, 2020.
Menni C., Valdes A.M., Freidin M.B. et al. Real-time tracking of self-reported symptoms to predict potential COVID-19. // Nat Med (2020). https://doi.org/10.1038/s41591-020-0916-2.
Nath A. Neurologic complications of coronavirus infections // Neurology. (2020) 94:809-10.
Poyiadji N., Shahin G., Noujaim D., Stone M., Patel S., Griffith B. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features // Radiology. (2020) 201187. doi: 10.1148/radiol.2020201187.
Romoli M, Jelcic I, Bernard-Valnet R et al. A systematic review of neurological manifestations of SARS-CoV-2 infection: the devil is hidden in the details. // Eurpean Journal of Neurology,05 june 2020.
Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge // Virol J. (2019) 16:69. doi: 10.1186/s12985-019-1182-0.
Suwanwongse K., Shabarek N. Rhabdomyolysis as a presentation of 2019 novel coronavirus disease // Cureus J. Med. Sci. 2020;12 doi: 10.7759/cureus.7561.
Sheraton M, Deo N, Kashyap R, et al. (May 18, 2020) A Review of Neurological Complications of COVID-19 // Cureus 12(5): e8192. doi:10.7759/cureus.8192.
Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia // J Thromb Haemost 2020; 18: 844-7.doi:10.1111/jth.14768.
Tsai LK, Hsieh ST, Chang YC. Neurological manifestations in severe acute respiratory syndrome // Acta Neurol Taiwan. (2005) 14:113-9.
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020 Feb 7. [Epub ahead of print] doi:10.1001/jama.2020.1585 pmid:32031570
Wan S, Yi Q, Fan S, Lv J, Zhang X, Guo L, et al. Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP). medRxiv (2020).
Welge-Lussen A, Wolfensberger M. Olfactory disorders following upper respiratory tract infections // Adv Otorhinolaryngol. 2006;63:125-32.
Wong SH, Lui RN, Sung JJ. Covid-19 and the digestive system // J Gastroenterol Hepatol. (2020) 35:744-8. doi: 10.1111/jgh.15047.
World Health Organization. Coronavirus disease 2019 (COVID-19) situation report-45. Accessed March 5, 2020. https://www.who.int/docs/defaultsource/coronaviruse/situation- reports/20200305-sitrep-45-covid19.pdf?sfvrsn=ed2ba78b_2.
Wu D., Wu T., Liu Q., Yang Z. The SARS-CoV-2 outbreak: What we know // International Journal of Infectious Diseases. 94 (2020) 44-48.
Yasgur B. Three Stages to COVID-19 Brain Damage, New Review Suggests - Medscape - Jun 29, 2020. https://www.medscape.com/viewarticle/933131
Yang X., Yu Y., Xu J. Clinical course and outcomes of critically ill patients with SARS- CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study // Lancet Respir. Med. 2020 doi: 10.1016/S2213-2600(20)30079-5. pii: S2213-2600 (20)30079-5. Published online Feb 24, 2020.
Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS- CoV-2 infection: causality or coincidence? // Lancet Neurol. (2020) 19:383-4. doi:10.1016/S1474-4422(20)30109-5.
Zhao K., Huang J., Dai D., Feng Y., Liu L., Nie S. Acute myelitis after SARS-CoV-2 infection: A case report. medRxiv Prep. 2020 doi: 10.1101/2020.03.16.20035105. Published online March 18, 2020. (accessed 4/24/2020)
Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, et al. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19 // J Thromb Haemost. 2020 Apr; 14859.
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