Neurogenetic Approaches of Perinatal Hypoxicischemic Affectionsof the Central Nervous System

N.J. Rahimova; A.K. Mammadbayli; G.M. Gurbanova

doi:10.61788/njn.v1i20.04

Authors

N.J. Rahimova Scientific Research Institute of Pediatrics named after K.Y.Farajeva, Baku, Azerbaijan
A.K. Mammadbayli Azerbaijan Medical University, Department of Neurology, Baku, Azerbaijan
G.M. Gurbanova Azerbaijan State Advanced Training Institute for Doctors named after A.Aliyev, department of Neurology and Clinical Neurophysiology, Baku, Azerbaijan

DOI:

https://doi.org/10.61788/njn.v1i20.04

Keywords:

hypoxic-ischemic affections of brain, newborns, epigenetics of perinatal brain affections

Abstract

Lately revealed new data on neurogenetics of perinatal affections of central nervous system (CNS). The degree of genetic determination of perinatal affections of CNS is not similar in different cases and might vary in wide ranges. Prematurity is main mechanism of genetic predetermination of perinatal affections of CNS. Beside direct affection to brain, all main ethio-pathogenetic factors of hypoxia-ischemic affections of CNS (hypoxia, malnutrition of pregnant, stresses, smocking, alcohol-drug abuse, prematurity) can cause epigenetic changes of neuro-expression with forming cerebral phenotype, which is sensitive to perinatal affections. So new data obliges to change approaches to prevention of perinatal affections of CNS.

References

UNICEF, WHO, World Bank, UN DESA/Population Division. Levels and Trends in Child Mortality Report 2019. https://www.who.int/maternal_child_adolescent/documents/levels_trends_child_mortality_2019/en/

Oestergaard MZ, Inoue M, Yoshida S, Mahanani WR, Gore FM, et al. (2011) Neonatal Mortality Levels for 193 Countries in 2009 with Trends since 1990: A Systematic Analysis of Progress, Projections, and Priorities. PLoS Med 8(8): e1001080. doi:10.1371/journal.pmed.1001080.

Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016;388(10063):3027-35.

Blencowe H, Cousens S, Oestergaard M, Chou D, Moller AB, Narwal R, Adler A, Garcia CV, Rohde S, Say L, Lawn JE. National, regional and worldwide estimates of preterm birth. The Lancet, June 2012. 9;379(9832):2162-72.

Zanelli SA, Stanley DP, Kaufman D. (2012). Hypoxicischemic encephalopathy [Электронныйресурс]. Available at: http://emedicine.medscape.com/article/973501 (date of access: 25.09.2012).

Петренко Ю.В., Иванов Д.О., Курзина Е.А. Оценка органной недостаточности у новорождённых // Бюллетень Федерального Центра сердца, крови и эндокринологии им. В.А. Алмазова. 2011; 2: 43-50.

Баранов А.А., Маслова O.И., Намазова-Баранова Л.С. Онтогенез нейрокогнитивного развития детей и подростков //Вестник Российской академии медицинских наук. 2012; 67(8):26-33.

Современные медико-социальные проблемы неонатологии /Под ред. А.А. Баранова, Г.В. Яцык. М.: ПедиатрЪ. 2015; 225-301.

Birney E, Soranzo N. Human genomics: The end of the start for population sequencing. Nature. 2015;526(7571):52-53.

Auton A, Brooks LD, Durbin RM, et al. A global reference for human genetic variation. Nature. 2015;526(7571):68-74.

Biggio JR, Anderson S. Spontaneous preterm birth in multiples.ClinObstet Gynecol. 2015;58(3):654-667.

Parets SE, Knight AK, Smith AK. Insights into genetic susceptibilityin the etiology of spontaneous preterm birth. Appl Clin Genet.2015;8:283-290.

Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiologyand causes of preterm birth. Lancet. 2008;371(9606):75-84.

Haataja R, Karjalainen MK, Luukkonen A, et al. Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis. PLoS Genet.2011;7(2):1008-1015.

Treloar SA, Macones GA, Mitchell LE, Martin NG. Genetic influences on premature parturition in an Australian twin sample. TwinRes. 2000;3(2):80-82.

Committee on Practice Bulletins-Obstetrics, TACoO, Gynecologists. Practice bulletin no 130: prediction and prevention of preterm birth. Obstet Gynecol. 2012;120(4):964-973.

Wu W, Witherspoon DJ, Fraser A, et al. The heritability of gestationalage in a two-million- member cohort: implications for spontaneous preterm birth. Hum Genet. 2015;134(7):803-808.

Wilcox AJ, Skjaerven R, Lie RT. Familial patterns of pretermdelivery: maternal and fetal contributions. Am J Epidemiol. 2008;167(4):474-479.

Plunkett J, Feitosa MF, Trusgnich M, et al. Mother’s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Hum Hered. 2009;68(3):209-219.

DiGiulio DB. Diversity of microbes in amniotic fluid. Semin FetalNeonatal Med. 2012;17(1):2-11.

Mendz GL, Kaakoush NO, Quinlivan JA. Bacterial aetiologicalagents of intra-amniotic infections and preterm birth in pregnant women. Front Cell Infect Microbiol. 2013;3:58.

Payne MS, Bayatibojakhi S. Exploring preterm birth as a polymicrobial disease: an overview of the uterine microbiome. Front Immunol. 2014;5:595.

Wood IS, de Heredia FP, Wang B, Trayhurn P. Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc. 2009; 68(4):370-377.

Milosevic J, Maisel M, Wegner F, et al. Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J Neurosci.2007;27(2):412-421.

Wang X, Meng FS, Liu ZY, et al. Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior.MolNeurobiol. 2013;48(3):544-555.

Antonow-Schlorke I, Schwab M, Cox LA, et al. Vulnerability of thefetal primate brain to moderate reduction in maternal global nutrient availability. Proc Natl Acad Sci U S A. 2011;108(7):3011-3016.

Florian ML, Nunes ML. Effects of intra-uterine and early extra-uterine malnutrition on seizure threshold and hippocampal morphometry of pup rats. NutrNeurosci.2011;14(4):151- 158.

Torres N, Bautista CJ, Tovar AR, et al. Protein restriction during pregnancy affects maternal liver lipid metabolism and fetal brain lipid composition in the rat. Am J Physiol Endocrinol Metab. 2010;298(2):E270-277.

Ranade SC, Sarfaraz Nawaz M, Kumar Rambtla P, et al. Early protein malnutrition disrupts cerebellar development and impairs motor coordination. Br J Nutr. 2012;107(8):1167-1175.

Melse-Boonstra A, Jaiswal N. Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development. Best Pract Res Clin Endocrinol Metab. 2010;24(1):29-38.

Sanches EF, Arteni NS, Spindler C, et al. Effects of pre- and postnatal protein malnutrition in hypoxic-ischemic rats. Brain Res. 2012;1438:85-92.

Tozuka Y, Wada E, Wada K. Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring. FASEB J.2009;23(6):1920-1934.

Neurogenetic Approaches of Perinatal Hypoxicischemic Affectionsof the Central Nervous System

Authors

DOI:

Keywords:

Abstract

References

Downloads

Published

How to Cite

Issue

Section

License

Menu

Keywords

Publisher