Morphometric Markers of Brain Atrophy in Multiple Sclerosis
DOI:
https://doi.org/10.61788/njn.v1i20.06Keywords:
multiple sclerosis, brain atrophy, morphometric markersAbstract
The aim of our work was to study the correlation between morphometric indicators оf brain atrophy and clinical symptoms in multiple sclerosis (MS). 88 patients (58 women, 30 men) with MS aged 18 to 60 years were under observation. 56 patients had relapse-remitting multiple sclerosis (RRMS), 32 patients had a secondary progressive multiple sclerosis (SPMS) type of disease course. All patients underwent magnetic resonance imaging with voxel morphometry. Established that SPMS manifested by more pronounced degenerative changes. In RRMS, the sequence of involvement of individual brain structures in the degenerative process was determined: atrophy of the subcortical gray matter ( thalamus) is detected in the early stages of the development of the disease, then the cortex is involved with the defeat of the central gyrus, and lastly, the white matter of the brain.
References
Şirəliyeva R.K. Dağınıq sklerozun differensial diaqnostikası // Milli nevrologiya jurnalı, 2012, №1, s.13-21.
Кротенкова М.В., Брюхов В.В., Морозова С.Н., Кротенкова И.А. Магнитно-резонансная томография в диагностике и дифференциальной диагностике рассеянного склероза. Руководство для врачей. М:ГЭОТАР-Медиа -2019, 160с.
Воронков Л.В., Труфанов А.Г., Фоксин В.А., и др. Возможности воксельбазированной морфометрии в диагностике неопухолевых заболеваний головного мозга // Вести. Рос.воен.мед.акад.2012., т.1, №1, с.10-2.
Ashburner J., Friston K.J., Voxel-based morphometry - the methods // Neuro Image. 2000, 11:805- 821.
Minagar A. The thalamus and multiple sclerosis: Modern views on pathologic, imaging and clinical aspects // “Neurology”, 2013-т.80.№2, 210-219.
Henry R.G., Shieh M. et al. Connecting white matter injury and thalamic atrophy in clinically isolated syndromes // J.Neurol.Sci.2009. т.282, №1.-2, 61-66.
Мусина Н.Ф. Когнитивные нарушения у больных рассеянным склерозом: сопряженность нейропсихологических, нейрофизиологических и нейровизуализационных характеристик // Бюллетень Сибирской медицины. 2008.т-7. №5. с.25-29.
Kali K. Retrograde cortical and axonal changes following lesions of the pyramidal tract // Brain Res.1995, т.89, №1,15-27c.
Al-Abdulla N.A. Apoptosis of retrogradely degenerating neurons occurs in association with the accumulation of perikaryal mitochondria and oxidative damage to the nucleus // Am.J.Pathol.1998, т.153, №2, 447-56.
Sailer M., Fischl B., Salat D. e.a. Focal thinning of the cerebral cortex in multiple sclerosis // Brain. -2003. т.-126, №8, 1734-1744.
Prinster A., Quarantelli M., Ozefice G. e.a. Grey matter loss in relapsing-remitting multiple sclerosis: A voxel-based morphometry study // Neuroimage.2006, т.29, №3, 859-867.
Pozzilli C., Passafiume D., Bernardi S. e.a. SPECT, MRJ and cognitive functions in multiple sclerosis // J. Neurol. Neurosurg. Psychiatry. 2001.-т.54, №2, 110-115.
Sfaqos C., Papageorgion C., Kosma K. e.a. Working memory deficits in multiple sclerosis a controlled study with auditory P600 currelates // J. Neurol. Neurosurg. Psychiatry. 2003.- т.74, №9,1231-1235.
Schmahmann J.D., Caplan D. Cognition, emotion and the cerebellum // Brain, 2006, т.129, №2, 290-292.
Raz E., Cercignani M., Sbardella E. e.a. Gray and white-matter changes 1 year after first clinical episode of multiple sclerosis: MR imaging // Radiology.2010, т.257, №2,448-54.
Morgan K., Sammer G., Courtney S. e.a. Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS // Neuroimage.2009, т.30, №3, 891-898.
Kutzelnigg A., Faber-Rod J.C., Bauer J. e.a. Widespread demyelination in the cerebellar cortex in multiple sclerosis // Brain Pathol.2007, т.17, №1, 38-44.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 National Association of Neurologists
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
