Adiponectin as a Risk Factor for the Development of Metabolic Disorders in Patients with Diabetic Polyneuropathy
DOI:
https://doi.org/10.61788/njn.v2i18.11Keywords:
diabetic polyneuropathy, type 2 diabetes, insulin resistance, adiponectin, correlationAbstract
The aim of the study was to assess the level of adiponectin in the blood serum in patients with diabetic polyneuropathy. The study involved 86 patients with diabetic polyneuropathy (DPN), of which men accounted for 64.0%, women – 36.0%. In the examined patients with DPN, the (Homeostasis model assessment) HOMA index on average exceeded the normative indices by 2.2 times (p<0.01). There were no significant differences in the rates between men and women. Only the insulin content in the blood and the HOMA-IR value in men were higher by 52.2% (p<0.05) and by 36.6% (p<0.05), respectively. The level of adiponectin in both men and women was significantly lower than the reference values, respectively 2.4 times (p<0.01) and 1.3 times (p<0.05). The increase in adiponectin in women was 1.5 times (p<0.05). The content of adiponectin in the blood in women correlated with the mean direct link to glycohemoglobin (r=+0.377), and in men the closest relationship of adiponectin with the insulin resistance index (r=+0.421) was revealed. The expediency of using the results of the level of adiponectin in the pathogenesis of DPN was established. The level of adiponectin is an important criterion for determining the degree of severity, control of treatment, as well as for determining the prognosis of the disease.
References
Головачева В.А., Зиновьева О.Е. Диабетическая полинейропатия: от науки к практике. Медицинский совет. 2015; 7: 18-22.
Котов С.В., Калинин А.П., Рудакова И.Г. Диабетическая нейропатия. Москва: МИА, 2011: 438.
Ybarra-Munoz J., Jurado-Campos J., Garcia-Gil M. et al. Cardiovascular disease predicts diabetic peripheral polyneuropathy in subjects with type 2 diabetes: A 10-year Prospective Study. European Journal of Cardiovascular Nursing, 2016; 15 (4): 248–254.
Ассоциация между уровнями адипоцитокина в сыворотке и микроангиопатиями у пациентов с сахарным диабетом 2-го типа J Diabetes Investig, 2014; 5(3)
Терещенко И.В., Каменских Я.А., Суслина А.А. Адипонектин в норме и патологии. Терапевтический архив. 2016;12:126-132 doi: 10.17116/terarkh20168812126-132
Li L., Chen J., Wang J., Cai D. Prevalence and risk factors of diabetic peripheral neuropathy in type 2 diabetes mellitus patients with overweight/obese in Guangdong province, China. Primary Care Diabetes, 2015; 9(3): р.191–195.
Мацуда М., Кавасаки Ф., Иноуэ Х. и др. Возможный вклад адипоцитокинов в диабетическую невропатию. Диабет Res Clin практике.2004; 66: S121-S123
Kato K, Osawa H, Ochi M. идр. Уровень адипонектина в сыворотке и высокомолекулярном уровне адипонектина коррелируют с тяжестью диабетической ретинопатии и нефропатии. Clin. Endocrinol., 2008;68: р.442-449
Chan‐Hee Jung, Bo‐Yeon Kim, Ji‐Oh Mok, Sung‐Koo Kang, Chul‐Hee Kim Association between serum adipocytokine levels and microangiopathies in patients with type 2 diabetes mellitus. J Diabetes Investig. 2014;5(3): 333-339.
World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects // JAMA, 2013, vol.310, Nо 20, р. 2191-2194.
Lindberg S, Jensen JS, Pedersen SH, Galatius S, Frystyk J, Flyvbjerg A, Bjerre M, Mogelvang R. Lindberg Low adiponectin levels and increased risk of type 2 diabetes in patients with myocardial infarction. Diabetes Care. 2014;37(11):3003-3008. doi:10.2337/dc14-093
Ma H, Cui F, Dong JJ, You GP, Yang XJ, Lu HD, Huang YL. Therapeutic effects of globular adiponectin in diabetic rats with nonalcoholic fatty liver disease. World J Gastroenterol. 2014; 20(40):14950-14957. doi:10.3748/wjg.v20.i40.14950
Савельева С.А., Крячкова A.A., Курумова К.О, Шамхалова М.Ш., Кутырина И.М., Шестакова М.В. Ожирение — фактор риска поражения почек у больных сахарным диабетом 2-го типа. Сахарный диабет. 2010;2:45-50.
Никитина И.Л., Тодиева А.М., Каронова Т.Л., Гринева Е.Н. Взаимосвязь уровня витамина D, содержания адипоцитокинов и метаболических нарушений у детей с ожирением. Бюллетень Федерального центра сердца, крови и эндокринологии им. В.А. Алмазова. 2013 Июнь: 37-46.
Li Y, Wu QH, Jiao ML, Fan XH, Hu Q, Hao YH, Liu RH, Zhang W, Cui Y., Han LY. Gene- environment interaction between adiponectin gene polymorphisms and environmental factors on the risk of diabetic retinopathy. J Diabet Invest. 2015;6(1):56-66. doi:10.1111/jdi.12249
Al-Hamodi Z, Al-Habori M, Al-Meeri A, Saif-Ali R. Assosiation of adipokines , leptin/adiponectin ratio and C-reactive protein with obesity and tipe 2 diabetes mellitus. Diabet Metabol Syndrome. 2014;6(1):99. doi:10.1186/1758-5996-6-9
Титов В.Н. Биологическая функция трофологии (питания) и патогенез метаболического синдрома - физиологического переедания. филогенетическая теория общей патологии, лептин и адипонектин. Кардиологический вестник. 2014;1:79-93.
Pereira RI, Snell-Bergeon JK, Erickson C, Shauer IE, Bergman BC, Rewers M, Maahs DM. Adiponectin dysregulation and insulin resistance in type 1 diabetes. J Clin Endocrinol Metabol. 2012;97(4):E642-647. doi:10.1210/jc.2011-2542
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