Сomparative Characteristic of Nerve Conduction Studies at Chronic Inflammatory Demyelinating Polyneuropathy and Hereditary Motorsensory Neuropathy Type 1
DOI:
https://doi.org/10.61788/njn.v1i18.03Keywords:
chronic inflammatory demyelinating polyneuropathy, hereditary motor sensory neuropathy 1 type, q, nerve conduction studiesAbstract
Results of the carried-out comparative analysis of nerve conduction studies indicators of 78 patients with demyelinating polyneuropathy (40 patients with the chronic inflammatory demyelinating polyneuropathy (CIDP) and 38 with hereditary motor and sensory neuropathy (NMSN) of type 1). It is revealed that nerve conduction studies characteristics of CIDP and NMSN of type 1 have similar lines in connection with the similar mechanism of a pathogeny - demyelination. The distinctive characteristic is uniformity of distribution of demyelinationat NMSN of type 1 in the form of uniform reduction of motor nerve conduction velocity (NCV) and compound motor action potential in the majority of the lesion peripheral nerves of extremities and high correlation dependence of indicators of NCV on tibialis on a longitudinal axis and with NCV on n.medialis and amplitude indicators at stimulation of n.medialis at patients with NMSN of type 1; patients with CIDP have a high variability and a symmetry of defeat with existence of conduction blocks and high correlation communication of amplitude indicators at stimulation of n.tibialis in distal and proximal departments.
References
Cottenie E, Menezes MP, Rossor AM, Morrow JM, Yousry TA, Dick DJ, et al. Rapidly progressive asymmetrical weakness in Charcot-Marie-Tooth disease type 4J resembles chronic inflammatory demyelinating polyneuropathy // Neuromuscul Disord. 2013 May;23(5):399-403.
Fujisawa M, Sano Y, Omoto M, Ogasawara J-I, Koga M, Takashima H, et al. Charcot- Marie-Tooth disease type 2 caused by homozygous MME gene mutation superimposed by chronic inflammatory demyelinating polyneuropathy // Rinsho Shinkeigaku. 2017 30;57(9):515-20.
Grimm A, Vittore D, Schubert V, Lipski C, Heiling B, Décard BF, et al. Ultrasound pattern sum score, homogeneity score and regional nerve enlargement index for differentiation of demyelinating inflammatory and hereditary neuropathies // Clin Neurophysiol. 2016 Jul;127(7):2618-24.
Hasegawa O, Matsumoto S, Iino M, Kurita R, Kubota Y. Comparison of electrophysiological findings between CIDP and HMSN-1 // No To Shinkei. 1999 May;51(5):411-4.
Iijima M. Phenotypes of Charcot-Marie-Tooth Syndrome and Differential Diagnosis Focused in Inflammatory Neuropathies // Brain Nerve. 2016 Jan;68(1):31-42.
Kang JH, Kim HJ, Lee ER. Electrophysiological evaluation of chronic inflammatory demyelinating polyneuropathy and charcot-marie-tooth type 1: dispersion and correlation analysis // J Phys Ther Sci. 2013 Oct;25(10):1265-8.
Kume K, Deguchi K, Ikeda K, Takata T, Kokudo Y, Kamada M, et al. Usefulness of the modified F-ratio for assessments of proximal conduction in chronic inflammatory demyelinating polyneuropathy superimposed on Charcot Marie-Tooth disease type 1A // J Neurol Sci. 2014 Aug 15;343(1-2):237-9.
Latov N. Biomarkers of CIDP in patients with diabetes or CMT1 // J Peripher Nerv Syst. 2011 Jun;16 Suppl 1:14-7.
Marques W, Funayama CAR, Secchin JB, Lourenço CM, Gouvêa SP, Marques VD, et al. Coexistence of two chronic neuropathies in a young child: Charcot-Marie-Tooth disease type 1A and chronic inflammatory demyelinating polyneuropathy // Muscle Nerve. 2010 Oct;42(4):598-600.
Niu J, Cui L, Liu M. Multiple Sites Ultrasonography of Peripheral Nerves in Differentiating Charcot-Marie-Tooth Type 1A from Chronic Inflammatory Demyelinating Polyradiculoneuropathy // Front Neurol. 2017;8:181.
Oka N, Kawasaki T, Unuma T, Shigematsu K, Sugiyama H. Different profiles of onion bulb in CIDP and CMT1A in relation to extracellular matrix. Clin Neuropathol. 2013 Oct;32(5):406-12.
Pareyson D. Differential diagnosis of Charcot-Marie-Tooth disease and related neuropathies // Neurol Sci. 2004 Jun;25(2):72-82.
Potulska-Chromik A, Ryniewicz B, Aragon-Gawinska K, Kabzinska D, Seroka A, Lipowska M, et al. Are electrophysiological criteria useful in distinguishing childhood demyelinating neuropathies? // J Peripher Nerv Syst. 2016 Mar;21(1):22-6.
Rajabally YA, Adams D, Latour P, Attarian S. Hereditary and inflammatory neuropathies: a review of reported associations, mimics and misdiagnoses // J Neurol Neurosurg Psychiatry. 2016;87(10):1051-60.
Sinclair CDJ, Miranda MA, Cowley P, Morrow JM, Davagnanam I, Mehta H, et al. MRI shows increased sciatic nerve cross sectional area in inherited and inflammatory neuropathies // J Neurol Neurosurg Psychiatry. 2011 Nov;82(11):1283-6.
Stanton M, Pannoni V, Lewis RA, Logigian EL, Naguib D, Shy ME, et al. Dispersion of compound muscle action potential in hereditary neuropathies and chronic inflammatory demyelinating polyneuropathy // Muscle Nerve. 2006 Oct;34(4):417-22.
Sugimoto T, Ochi K, Hosomi N, Takahashi T, Ueno H, Nakamura T, et al. Ultrasonographic nerve enlargement of the median and ulnar nerves and the cervical nerve roots in patients with demyelinating Charcot-Marie-Tooth disease: distinction from patients with chronic inflammatory demyelinating polyneuropathy // J Neurol. 2013 Oct;260(10):2580-7.
Zaidman CM, Harms MB, Pestronk A. Ultrasound of inherited vs. acquired demyelinating polyneuropathies // J Neurol. 2013 Dec;260(12):3115-21.
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