Clinical Characteristics of Patients with Multiple Sclerosis and Optic Neuritis in The Debut

Abstract

Multiple sclerosis is a progressive disease with a variable profile and severe pathophysiological mechanisms that generate and affect pathomorphological changes that are consistent or accompanying in the central nervous system. The aim of the article is to analyze the clinical characteristics of patients with multiple sclerosis and optic neuritis in the debut. The study presents data from 41 patients with multiple sclerosis with the onset of optical neuritis, 19 of them women and 22 men. The age of patients ranged from 19 to 56 years, the average age was 33.2±1.5 years. The average duration of the disease is 2.6±0.3 years. Analyzing the data of clinical and electrophysiological examinations in 31 patients (78.0±6.5%), elongation of the latency of the visual induced response was revealed with stimulation of clinically healthy and in 36 patients (87.8±5.1%)-the affected eye. Subclinical changes in the contralateral “healthy” eye indicate dissemination within the visual system. Thus, in 31 patients (78.0±6.5%) without clinical manifestations of visual disturbances in the healthy eye, the involvement of the visual pathway into the pathological process at the subclinical stage of its lesion was detected.