The Close Relationship Between Apnea, Epilepsy and SUDEP
DOI:
https://doi.org/10.61788/njn.v1i27.02Keywords:
sleep apnea, sleep-related epilepsy, SUDEP, diagnosis, therapy, sultiamAbstract
A review of recent publications about sleep apnea and epilepsy has been shown that the respiratory system plays a crucial role in the development of sudden unexpected death in epilepsy (SUDEP). Sleep apnea can provoke or worsen epilepsy, and treatment of sleep apnea can reduce the number of seizures. The International Antiepileptic League identifies a special group of sleep-related epilepsies (sleep-accentuated epilepsies; sleep-associated epilepsies; epilepsy of awakening), among which, first of all, apnea screening should be carried out. In patients with apnea and epilepsy, the use of medications and therapies that cause or exacerbate apnea attacks should be limited. Apnea therapy should be used in a comprehensive and individualized way, in particular, treatment of obesity, CPAP therapy, sultiam (from 200 mg/day for adult patients with apnea and epilepsy), treatment of ENT pathology, etc. are recommended.
References
Maguire MJ, Jackson CF, Marson AG, Nevitt SJ. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). Cochrane Database Syst Rev. 2020 Apr 2;4(4):CD011792. doi: 10.1002/14651858.CD011792.pub3.
McCarter AR, Timm PC, Shepard PW, et al. Obstructive sleep apnea in refractory epilepsy: A pilot study investigating frequency, clinical features, and association with risk of sudden unexpected death in epilepsy // Epilepsia. 2018;59(10):1973-1981
Ryvlin P, Nashef L, Lhatoo SD. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study // Lancet Neurol. 2013;12:966-977
Susan Lin, Theodore H Schwartz, Geoffrey S Pitt, Sudden unexpected death in epilepsy: respiratory vs. cardiac contributions // Cardiovascular Research, 2024;, cvae170, https://doi.org/10.1093/cvr/cvae170
Hutson, T. Noah et al. Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP // IEEE Open Journal of Engineering in Medicine and Biology 1 (2020): 301-311
Meletti S, Duma GM, Burani M, Danieli A, et al. Ictal and Postictal Central Apnea in DEPDC5-Related Epilepsy // Neurol Genet. 2024 Aug 12;10(5): e200183. doi: 10.1212/NXG.0000000000200183
Samanta D. DEPDC5-related epilepsy: A comprehensive review // Epilepsy Behav. 2022 May;130:108678. doi: 10.1016/j.yebeh.2022.108678
Goyal M, Mishra P, Jaseja H. Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity // Int J Physiol Pathophysiol Pharmacol. 2023 Aug 15;15(4):105-114
Carosella CM, Gottesman F, Kucharska-Newton A, Lutsey PL, et al. Sleep apnea, hypoxia, and late-onset epilepsy: the Atherosclerosis Risk in Communities study // Sleep, Volume 47, Issue 6, June 2024, zsad233, https://doi.org/10.1093/sleep/zsad233.
Micalizzi E, Ballerini A, Giovannini G, Cioclu MC, Scolastico S, Pugnaghi M, Orlandi N, Malagoli M, Genovese M, Todeschini A, Giunta L, et al. Роль миндалины в иктальном центральном апноэ: результаты МРТ-морфометрии головного мозга. Ann Clin Transl Neurol. 2024 Январь; 11(1): 121-132. doi: 10.1002/acn3.51938.
Sivathamboo S, Myers KA, Pattichis A, White EJ, et al. Sleep and respiratory abnormalities in adults with developmental and epileptic encephalopathies using polysomnography and video-EEG monitoring // Epilepsia Open. 2023 Sep;8(3):1157-1168. doi: 10.1002/epi4.12772. Epub 2023 Jun PMID: 37277988; PMCID: PMC10472408.
Nobili L, de Weerd A, Rubboli G, Beniczky S, et al. Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review // Eur J Neurol. 2021 Jan;28(1):15-32. doi: 10.1111/ene.14468.
Goyal M, Mishra P, Jaseja H. Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity // Int J Physiol Pathophysiol Pharmacol. 2023 Aug 15;15(4):105-114.
Литвин А.Ю., Чазова И.Е., Елфимова Е.М., Певзнер А.В. и др. Клинические рекомендации Евразийской Ассоциации Кардиологов (ЕАК)/Российского общества сомнологов (РОС) по диагностике и лечению обструктивного апноэ сна у пациентов с сердечно-сосудистыми заболеваниями // Евразийский Кардиологический Журнал. 2024;(3):6-27. https://doi.org/10.38109/2225-1685-2024-3-6-27
Savini S, Ciorba A, Bianchini C, Stomeo F, et al. Assessment of obstructive sleep apnoea (OSA) in children: an update // Acta Otorhinolaryngol Ital. 2019 Oct;39(5):289-297. doi: 10.14639/0392-100X-N0262
Kubilay U, Agayarov OY, Arslan BO, Sancaktar O, et al. A Novel Screening Tool for Severe Obstructive Sleep Apnea // Ear Nose Throat J. 2024 Oct 11:1455613241279654. doi: 10.1177/01455613241279654
Chung F, Yegneswaran B, Liao P, Chung SA, et al. STOP questionnaire: a tool to screen patients for obstructive sleep apnea // Anesthesiology. 2008 May;108(5):812-21. doi: 10.1097/ALN.0b013e31816d83e4
Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome // Ann Intern Med. 1999 Oct 5;131(7):485-91. doi: 10.7326/0003-4819-131-7-199910050-00002
Javaheri S, Randerath WJ, Safwan Badr M, Javaheri S. Medication-induced central sleep apnea: a unifying concept // Sleep. 2024 Aug 14;47(8):zsae038. doi: 10.1093/sleep/zsae038. Erratum in: Sleep. 2024 Aug 14;47(8):zsae127. doi: 10.1093/sleep/zsae127
Linselle M, Montastruc F, Jantzen H, Valnet-Rabier MB, et al. Drugs and Sleep Apneas? A review of the French Pharmacovigilance database // Therapie. 2015 Jul-Aug;70(4):347-50. doi: 10.2515/therapie/2014218. Epub 2015 Feb 16
Linselle M, Sommet A, Bondon-Guitton E, Moulis F, et al. Can drugs induce or aggravate sleep apneas? A case-noncase study in VigiBase® , the WHO pharmacovigilance database // Fundam Clin Pharmacol. 2017 Jun;31(3):359-366. doi: 10.1111/fcp.12264
Revol B, Jullian-Desayes I, Guichard K, Micoulaud-Franchi JA, et al. Valproic acid and sleep apnoea: A disproportionality signal from the WHO pharmacovigilance database // Respirology. 2020 Mar;25(3):336-338.
Maguire MJ, Jackson CF, Marson AG, Nevitt SJ. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). Cochrane Database Syst Rev. 2020 Apr 2;4(4):CD011792. doi: 10.1002/14651858.CD011792.pub3.
Monté CPJA, Arends JBAM, Lazeron RHC, Tan IY, Boon PAJM. Update review on SUDEP: Risk assessment, background & seizure detection devices // Epilepsy Behav. 2024 Oct 8;160:109966. doi: 10.1016/j.yebeh.2024.109966
Bradicich M, Siciliano M, Schiavi E, Amante E, et al. ERS International Congress 2022: highlights from the Sleep Disordered Breathing Assembly // ERJ Open Res. 2023 Apr 17;9(2):00582-2022. doi: 10.1183/23120541.00582-2022.
Hedner J, Stenlöf K, Zou D, Hoff E, et al. A Randomized Controlled Clinical Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea // Am J Respir Crit Care Med. 2022 Jun 15;205(12):1461-1469. doi: 10.1164/rccm.202109-2043OC
Leonard JA, Blumenthal DL, Almasri MM, Zalzal H, Riley CA, Lawlor CM. Management of Obstructive Sleep Apnea in the Infant: A Systematic Review and Meta-analysis // Otolaryngol Head Neck Surg. 2024 Oct 19. doi: 10.1002/ohn.1021
Abid R, Zhang L, Bhat A. Non-CPAP Therapies for Obstructive Sleep Apnea in Adults // Mo Med. 2024 Sep-Oct;121(5):385-390
Cielo CM, Tapia IE. What's New in Pediatric Obstructive Sleep Apnea? // Sleep Med Clin. 2023 Jun;18(2):173-181. doi: 10.1016/j.jsmc.2023.02.002
Pépin JL, Lehert P, Ben Messaoud R, Joyeux-Faure M, et al. Comparative efficacy, safety and benefit/risk of alerting agents for excessive daytime sleepiness in patients with obstructive sleep apnoea: a network meta-analysis // EClinicalMedicine. 2024 Sep 19;76:102843. doi: 10.1016/j.eclinm.2024.102843.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 National Association of Neurologists

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



