The Role of The Hormone Adiponectin in The Development of Diabetic Polyneuropathy
DOI:
https://doi.org/10.61788/njn.v2i17.10Keywords:
Diabetic polyneuropathy, hyperglycemia, endoneural vessel, adiponectinAbstract
One of the serious complications of diabetes, contributing to the development of disability and mortality, is diabetic polyneuropathy. Hyperglycemia causes disturbance of metabolic processes that trigger a cascade of metabolic disorders endoneural blood vessels, which in turn leads to disruption of supply of nerve fibers (hypoxia) and destructive changes of the latter. Adiponectin is a hormone gene associated with the development of type 2 diabetes and its complications. Identification of the genetic determinants of the development and progression of diabetic neuropathy will prevent the development of complications of type 2 diabetes - to diagnose and provide a personalized approach.
References
Дедов И.И. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Москва, 2008 г, 56 с.
Carmeliet P., Storkebaum E: Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin Cell Dev Biol, 2002. 13: 39-53
Балаболкин М.И. Диабетология. — Москва. Медицина, 2000. — 672 с.
Boulton A. J., Malik R. A., Arezzo J. C., Sosenco J. M. Diabetic Somatic Neuropathies. Diab. Care, Vol. 27, N 6, Jun 2004, p:1458-1486
Моргоева Ф.Э., Аметов А.С., Строков И.А. Диабетическая энцефалопатия и полиневропатия: терапевтические возможности актовегина // РМЖ. — 2005. — Том 13, № 6. — С. 1-3.
Akbari C.M., Gibbons G.W., Habershaw G.M., et al. The effect of arterial reconstruction on the natural history of diabetic neuropathy. Arch-Surg 132:148-152, 1997
Giannini C., Dyck P.J. // Diabetic Neuropathy / Eds P.J. Dyck, P.K.Thomas. - 2-nd Ed. - Philadelphia, 1999. - P. 279 295.
Airey M., Bennett C., Nicolucci A., Williams R: Aldose reductase inhibitors for the prevention and treatment of diabetic peripheral neuropathy. Cochrane Database Syst Rev 2:CD002182, 2000.
Brunetti A., Chiefari E., Foti D. Recent advances in the molecular genetics of type 2 diabetes mellitus. World Journal Diabetes. 2014;5(2):128-40.
Billings L.K, Florez J.C. The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci 2010; 1212: 59-77.
Dorajoo R, Liu J, Boehm BO et al. Genetics of Type 2 Diabetes and Clinical Utility. Genes (Basel). 2015;6(2):372-84.
Diaz-Ganete A., Baena-Nieto G., Lomas-Romero IM et al. Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality. Int J Endocrinol. 2015; 2015:235727.
Prakash J., Mittal B., Awasthi S. et al. Hypoadiponectinemia in obesity: association with insulin resistance. Indian J Clin Biochem. 2013; 28(2):158-63.
Kuo J.Z., Wong T.Y., Rotter J.I. Challenges in elucidating the genetics of diabetic retinopathy. JAMA Ophthalmol. 2014;132(1):96-107.
Kwak SH, Park KS. 147 Genetic Studies on Diabetic Microvascular Complications: Focusing on Genome-Wide Association Studies. Endocrinol Metab (Seoul). 2015;30(2):147-58.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 National Association of Neurologists
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
